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M Forhotdate Date Szh 1 For Hot Date 专家人才----中国科学院广州生物医药与健康研究院

M Forhotdate Date Szh 1 For Hot Date

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现在位置：

简历：
  • 1987-1993     加拿大McMaster大学生物系遗传学博士
    1980-1984     华中农业大学农学系学士 
  • 2004至今       中国科学院广州生物医药与健康研究院，研究员
    2001-2003     生物芯片北京国家工程中心，首席科学家
    1999-2001     美国GCG生物信息公司，项目经理
    1997-1999     美国强生Scios制药公司生物信息部，研究员
    1997-1997     美国Quest Diagnostics医疗诊断公司研发部，研究员
    1994-1997     美国芝加哥大学生态与进化系，博士后

研究领域：
  • 人类重大疾病诊断技术研发；
  • 国内外违禁、限用小分子兽药残留检测技术研发；
  • 基于量子点的液相芯片和生物传感器的研发； 
  • 干细胞标志物及iPS的研究。
社会任职：

获奖及荣誉：
代表论著：

  • Jiekai Chen, Jing Liu, Jiaqi Yang, You Chen, Jing Chen, Su Ni, Hong Song, Lingwen Zeng, Ke Dingand Duanqing Pei .BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone. Cell Research (2011) 21:205–212.（8.151）

  • Zhiyuan Fang, Jing Huang, Puchang Lie, Zhuo Xiao, Chuanyan Ouyang, Qing Wu, Yixing Wu, Guodong Liu* and Lingwen Zeng*Lateral flow nucleic acid biosensor for Cu2+ detection in aqueous solution with high sensitivity and selectivity Chem. Commun., 2010, 46, 9043-9045 (5.504)

  • Li R, Liang J, Ni S, Zhou T, Qing X, Li H, He W, Chen J, Li F, Zhuang Q, Qin B, Xu J, Li W, Yang J, Gan Y, Qin D, Feng S, Song H, Yang D, Zhang B, Zeng L, Lai L, Esteban MA, Pei D. 2010. A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts. Cell Stem Cell. 2010 Jul 2;7(1):51-63.（23.563）

  • Cai J, Li W, Su H, Qin D, Yang J, Zhu F, Xu J, He W, Guo H, Labuda K, Peterbauer A, Wolbank S, Zhong M, Li Z, Wu W, So KF, Redl H, Zeng L, Esteban MA, Pei D. Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells J. Biol. Chem. 2010；285（15）：11227-11234.（5.328）

  • Chen J, Liu J,Han Q,Qin D, Xu J ,Chen Y,Yang J,Song H, Yang D,Peng M,He W, Li R, Wang H,Gan Y,Ding K,Zeng L,Lai L,Esteban MA,Pei D.Towards an optimized culture medium for the generation of mouse induced pluripotent stem cells.J Biol Chem .2010 Jul 1.(5.328)

  • Esteban MA, Wang T, Qin B, Yang J, Qin D, Cai J, Li W, Weng Z, Chen J, Ni S, Chen K, Li Y, Liu X, Xu J, Zhang S, Li F, He W, Labuda K, Song Y, Peterbauer A, Wolbank S, Redl H, Zhong M, Cai D, Zeng L, Pei D. Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells. Cell Stem Cell. 2010 Jan 8: 6(1):71-79（23.563）

  • Su-min Li, Ling-wen Zeng, Lin Feng and Dong-bao Chen* Rac1-Dependent Intracellular Superoxide Formation Mediates Vascular Endothelial Growth Factor–Induced Placental Angiogenesis in Vitro.Endocrinology 2010 151:5315-5325 (5.313)

  • Mao X, Xu H, Zeng Q,Zeng L, Liu G. Molecular beacon-functionalized gold nanoparticles as probes in dry-reagent strip biosensor for DNA analysis. Chem Commun (Camb). 2009 Jun 7;(21):3065-7（5.34）

  • Liu G, Mao X, Phillips JA, Xu H, Tan W, Zeng L. Aptamer-Nanoparticle Strip Biosensor for Sensitive Detection of Cancer Cells. Anal Chem. 2009 Dec 15;81(24):10013-8（5.712）

  • Mao X, Ma Y, Zhang A, Zhang L,Zeng L, Liu G.. Disposable nucleic acid biosensors based on gold nanoparticle probes and lateral flow strip. Anal Chem. 2009 Feb ;81(4):1660-8（5.712）

  • Qin D, Gan Y, Shao K, Wang H, Li W, Wang T, He W, Xu J, Zhang Y, Kou Z, Zeng L, Sheng G, Esteban MA, Gao S, Pei D. Mouse Meningiocytes Express Sox2 and Yield High Efficiency of Chimeras after Nuclear Reprogramming with Exogenous Factors.J. Biol. Chem. 2008 283: 33730-5.（5.52）

  • Gao W, Li X, Zeng L, Peng T. Rapid isothermal detection assay: a probe amplification method for the detection of nucleic acids. Diag Microbiol Infect Dis.  2008,  60: 133-141.（2.139）

  • Chen Q, Li X, He W, Zhang H, Gao A, Cheng Y, Lei Y, Li S and Zeng L (2007) The epitope study of a-fodrin autoantibody in primary Sjögren's syndrome. Clinical and Experimental Immunology 149(3):497-503.（2.853）

  • Gao A, Chen Q, Cheng Y, Lei J, Zeng L (2007) Preparation of monoclonal antibodies against a derivative of semicarbazide as a metabolic target of nitrofurazone. Analytica Chinica Acta 592(1):58-63.（3.146）

  • Zeng L, J. M. Cameron, B. Chen and M. Kreitman 1998 The molecular clock revisited: the rate of synonymous vs. replacement change in Drosophila. Genetica 102-103(1-6):369-82.（1.98）

  • Hasson, E., I.-N. Wang, Zeng L, M. Kreitman and W. F. Eanes 1998 Nucleotide variation in the triosephosphate isomerase (Tpi) locus of Drosophila melanogaster and Drosophila simulans. Mol Biol Evol 15(6):756-69.（7.28）

  • Joly, D., C. Bazin, Zeng L and R. S. Singh 1997 Genetic basis of sperm and testis length differences and epistatic effect on hybrid inviability and sperm motility between Drosophila simulans and Drosophila sechellia.Heredity 78:354-62（3.823）

  • Zeng L. and M. Kreitman 1996 A simple strategy for sequencing cDNA clones. BioTechniques 21:446-52.

  • Zeng L. and M. Kreitman 1996 pZErO-Z, a modified vector for rapid PCR product cloning and DNA sequencing. Trends in Genetics, Technical Tips Online #TL10017.（8.659）

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